Role of HMGB1 in inflammatory pathogenesis of neurodegenerative diseases
10.3969/j.issn.1000-484X.2025.02.037
- VernacularTitle:HMGB1在神经变性疾病炎症反应过程中的作用研究进展
- Author:
Nan JIANG
1
;
Zhibin DING
;
Ting YANG
;
Miaomiao HOU
;
Hongxia HAN
;
Cungen MA
;
Lijuan SONG
;
Xinyi LI
Author Information
1. 山西医科大学第三医院(山西白求恩医院,山西医学科学院,同济山西医院)神经内科,太原 030032
- Publication Type:Journal Article
- Keywords:
High mobility group box 1;
Neurodegenerative diseases;
Inflammation
- From:
Chinese Journal of Immunology
2025;41(2):472-478
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are a group of chronic progressive diseases characterized by inflammation,degenera-tion and apoptosis.Chronic neuroinflammation is gradually becoming a potential pathogenic and predisposing factor.As a widely expressed non-histone nucleoprotein,HMGB1 participates in inflammatory process of human body through receptors of advanced glycation end products and Toll-like receptors while maintaining chromosome homeostasis.As a key factor of neuroinflammation,HMGB1 is widely involved in development of neurodegenerative diseases and may become a biomarker and a potential therapeutic target of neurodegenerative diseases.This article reviews the role of HMGB1 in neurodegenerative diseases and tries to provide ground-work for basic research and clinical application for targeting HMGB1 in the treatment of neurodegenerative diseases.
