Research progresses in the functions of oocyte mitochondria
10.3760/cma.j.cn101441-20201030-00593
- VernacularTitle:卵母细胞线粒体功能的研究进展
- Author:
Na ZHANG
1
;
Siman SUN
1
;
Wei YUE
1
;
Mo LI
1
Author Information
1. 北京大学第三医院生殖医学中心，北京 100191
- Publication Type:Journal Article
- Keywords:
Oocyte, maturation;
Mitochondria;
Aging, oocyte;
Mitochondrial replacement therapy
- From:
Chinese Journal of Reproduction and Contraception
2022;42(5):528-532
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are the most abundant organelles in oocytes. Successful fertilization and embryo development are heavily dependent upon inherent qualities of the oocytes, and thus reliant upon mitochondrial function of oocyte maturation. In addition to energy supply,mitochondria are multifunctional organelles that involved in many biological processes such as protein homeostasis in the cytoplasm and intracellular signaling pathways. With the development of assisted reproductive technology, more and more researches focus on the function of mitochondria on oocytes maturation, aging and pre-implantation embryonic development. In this review, we discuss the functions and changes of mitochondria during oogenesis, focusing on the consideration for therapeutic applications of mitochondrial replacement therapy in the treatment of mitochondrial diseases.
