Research progress of uterine fluid extracellular vesicles in endometrial receptivity
10.3760/cma.j.cn101441-20210305-00100
- VernacularTitle:宫腔液细胞外囊泡在子宫内膜容受性中的研究进展
- Author:
Yumeng REN
1
;
Hongjing HAN
1
Author Information
1. 北京大学人民医院生殖医学中心，北京 100044
- Publication Type:Journal Article
- Keywords:
Endometrial receptivity;
Uterine fluid;
Extracellular vesicles;
Embryo implantation
- From:
Chinese Journal of Reproduction and Contraception
2022;42(7):746-750
- CountryChina
- Language:Chinese
-
Abstract:
Endometrial receptivity refers to the ability of the endometrium to allow blastocyst location, adhesion, penetration, implantation, and to promote embryo implantation and development. The study of endometrial characteristics during implantation to find markers of endometrial receptivity has long been a hot topic of research. Although progress has been made, there is still a lack of recognized markers for predicting clinical pregnancy. Recent studies have shown that aspiration of uterine fluid has no negative effect on embryo implantation and can be studied as a non-invasive test. At the same time, it was found that there were extracellular vesicles in uterine fluid, in which miRNA, protein, DNA and lipid play an important role in the reproductive process of follicle development and maturation, embryo development and implantation, etc., and it is expected to be used as endometrial receptivity markers and therapeutic targets in the future. In this article, we will review the research progress of uterine fluid extracellular vesicles in the evaluation of endometrial receptivity.
