Live birth after transplantation of cryopreserved ovarian tissue with two-year follow-tup: report of the first Chinese case
10.3760/cma.j.cn101441-20210719-00312
- VernacularTitle:中国首例卵巢组织冷冻移植活产2年随访
- Author:
Ningxia SUN
1
;
Ziyuan LI
1
;
Wenjuan PANG
1
;
Liang WANG
1
;
Wen LI
1
Author Information
1. 海军军医大学附属长征医院生殖医学中心，上海 200003
- Publication Type:Journal Article
- Keywords:
Cryopreservation;
Premature ovarian insufficiency;
Fertility preservation;
In vitro activation;
Ovarian tissue transplantation
- From:
Chinese Journal of Reproduction and Contraception
2021;41(11):1026-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the safety and efficacy of in vitro activation (IVA) following cryopreserved ovarian tissue autotransplantation in the treatment of patients with premature ovarian insufficiency (POI). Methods:We reported and reviewed the treatment and follow-up of a patient with POI, who underwent IVA combined with cryopreserved ovarian tissue transplantation.Results:The patient naturally concepted and delivered a healthy baby boy, who became the first live birth after cryopreserved ovarian tissue transplantation in China. The baby showed normal physical, motor and mental development during two-year follow-up.Conclusion:IVA combined with cryopreserved ovarian tissue transplantation can effectively activate residual follicles in some POI patients and allow them to conceive their own genetic offspring. IVA technology may become a new choice for fertility treatment of POI patients.
