Non-invasive detection of rat skin scars using terahertz time-domain spectroscopy technology
10.3969/j.issn.1005-202X.2025.02.013
- VernacularTitle:基于太赫兹时域光谱技术的大鼠皮肤瘢痕无创检测
- Author:
Yimingjiang MUREZIYA
1
;
Shaohui GENG
;
Yiwei GUAN
;
Chunli SHEN
;
Jingqi WEN
;
Guangrui HUANG
Author Information
1. 北京中医药大学生命科学院,北京 102446
- Publication Type:Journal Article
- Keywords:
skin scar;
terahertz time-domain spectroscopy;
principal component analysis
- From:
Chinese Journal of Medical Physics
2025;42(2):227-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference in terahertz signal characteristics between rat skin scar and normal skin using terahertz time-domain spectroscopy technology,thereby providing a novel non-invasive detection technique for the pathological examination of skin scars.Methods A rat model of whole-layer skin defect was prepared,and a reflectance terahertz time-domain spectroscopy system was used to obtain the terahertz signal maps of normal skin and scarred area.Results The terahertz signals of normal skin showed two obvious reflection time-domain signal peaks,and the characteristics of the reflection peaks at different reflection points were relatively regular.The terahertz signals of skin scar also had two obvious reflection time-domain signal peaks,but the highest peak was lower than that of normal skin.In addition,principal component analysis revealed that skin scar signals and normal skin signals were clustered together separately.The terahertz signal at different sites differed significantly(P<0.05).Conclusion Terahertz time-domain spectroscopy technology can be applied to the non-invasive detection of skin scarring,exhibiting a good application prospect in biomedicine.
