Analysis of major factors of mosic embryo in blastocyst stage
10.3760/cma.j.cn101441-20201207-00664
- VernacularTitle:囊胚期胚胎嵌合发生主要影响因素分析
- Author:
Shengrong DU
1
;
Lei YANG
1
;
Zhiqing HUANG
1
;
Yunhong LIN
1
;
Qingfen CHEN
1
;
Beihong ZHENG
1
Author Information
1. 福建省妇幼保健院生殖医学中心，福建医科大学附属医院，福州 350001
- Publication Type:Journal Article
- Keywords:
Mosaic embryo;
Preimplantation genetic testing;
Advanced age;
Next generation sequencing
- From:
Chinese Journal of Reproduction and Contraception
2021;41(11):986-990
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze of the main influecing factors of mosic embryos during the preimplantation genetic test for chromosomal structural rearrangement (PGT-SR) to avoid the increase of risk of abortion and genetic abnormalities and to improve the diagnostic rate of mosic embryos.Methods:We used a retrospective cohort study to analyze 94 cycles of infertile patients undergoing PGT-SR and 551 cycles of intracytoplasmic sperm injection (ICSI) from January 2018 to December 2019 in the Reproductive Medical Center of the Maternal and Child Health Hospital. The relationship of mosic embryos was analyzed between the age, the number of oocytes, gonadotropin (Gn)/oocyte, the grade of blastocysts and chromosome carrier of different genders by the SPSS21.0 software.Results:In the PGT-SR cycle, single factor analysis found that mosaic embryos were related to age and sperm concentration ( P=0.02, P=0.04), but multivariate logistic regression analysis showed that age ( OR=3.41, 95% CI=1.34-8.66, P=0.01), sperm concentration ( OR=0.41, 95% CI=0.17-0.96, P=0.04) and chromosome carrier of different genders ( OR=2.21, 95% CI=1.04-4.70, P=0.04) were the main factors of embryo mosaicism. Conclusion:Female age, sperm concentration and chromosome carrier of different genders maybe affect the formation of mosaic embryos, providing theoretical basis for selective transfer of mosaic embryos.
