Clinical manifestations and imaging diagnosis of fibrocystic osteitis secondary to hyperparathyroidism
10.3969/j.issn.1002-1671.2025.08.006
- VernacularTitle:甲状旁腺功能亢进症继发纤维囊性骨炎的临床表现及影像诊断
- Author:
Jinman ZHONG
1
;
Yanmeng DENG
Author Information
1. 西安交通大学第二附属医院医学影像科,陕西 西安 710004
- Publication Type:Journal Article
- Keywords:
fibrocystic osteitis;
bone brown tumor;
primary hyperparathyroidism;
secondary hyperparathyroidism
- From:
Journal of Practical Radiology
2025;41(8):1280-1283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical manifestations and imaging diagnostic value of fibrocystic osteitis secondary to hyperparathyroidism(HPT).Methods The clinical and imaging data of 33 patients with fibrocystic osteitis secondary to HPT confirmed by clinical and pathological diagnosis were retrospectively analyzed.Results Among the 33 patients,there were 17 cases of primary hyperparathyroidism(PHPT),of which 9 cases were parathyroid adenomas,5 cases were parathyroid hyperplasia and 3 cases were parathyroid adenoma with hyperplasia.All 16 cases were secondary HPT,all with a history of chronic kidney disease;9 cases were secondary to end-stage renal disease,and 7 cases were secondary to stage 3 chronic kidney disease.Laboratory examinations showed elevated parathyroid hormone(PTH)levels in all cases.Among the 33 patients,26 cases had multiple skeletal involvements,with the pelvis being the most commonly involved site;7 cases had single-bone involvement;19 cases had associated pathological fractures;23 cases had multiple osteoporosis,and 10 cases had osteosclerosis.All cases showed that lesions were osteolytic or expansive bone destruction with sclerotic boundary.The soft tissues surrounding bone lesions were thickened in 11 cases,and the soft tissue masses were formed in 9 cases.Conclusion The clinical manifestations of fibrocystic osteitis are complex,but it exhibits certain imaging characteristics,which presents generalized osteoporosis with/without increased bone mineral density.Lesions of varying sizes show osteolytic or expansive bone destruction with sclerotic boundary.The pelvis is the most commonly affected site.Combined use of X-ray and CT laboratory tests such as serum calcium and PTH levels aids in the early diagnosis of this disease.
