Effects of serum prolactin levels at basal and stimulated status on outcomes of patients undergoing in vitro fertilization/intracytoplasmic sperm injection in gonadotropin agonist long protocol
10.3760/cma.j.cn101441-20200724-00413
- VernacularTitle:泌乳素血清基础水平及卵巢刺激后增幅对长方案IVF/ICSI助孕结局的影响
- Author:
Duoduo ZHANG
1
;
Jingran ZHEN
1
;
Qi YU
1
Author Information
1. 国家妇产疾病临床医学研究中心，中国医学科学院北京协和医院妇科内分泌与生殖中心，北京 100730
- Publication Type:Journal Article
- Keywords:
Prolactin;
Fertilization in vitro;
Sperm injection, intracytoplasmic;
Clinical pregnancy rate;
Live birth rate
- From:
Chinese Journal of Reproduction and Contraception
2022;42(2):150-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine whether basal prolactin levels impact pregnancy outcomes of the patients who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) procedures rely on endogenous gonadotropin. Methods:This retrospective cohort study finally included 3009 patients from July 1st, 2014 to March 31st, 2018 receiving IVF/ICSI cycles owing to tubal or male factors in Center for Gynecological Endocrinology & Reproductive Medicine, Peking Union Medical College Hospital. We compared assisted reproductive outcomes among patients according to their median prolactin levels (16.05 μg/L). Subgroup analyses divided by different prolactin levels were done through multifactor analyses. A repeated analysis of variance was used to illustrate the relationship between the scale of prolactin grows while stimulating and cumulative pregnancy outcomes.Results:There were more number of oocytes retrieved [9 (5,12)] and embryos [6 (3,10)] in those with basal prolactin above the median level (>16.05 μg/L) compared with patients with basal prolactin ≤16.05 μg/L [8(5, 11), P=0.013; 5(3, 9), P=0.015]. Prolactin beyond 30 μg/L was beneficial to cumulative clinical pregnancy ( OR=1.281, 95% CI=1.030-1.764, P=0.046) and prolactin above 40 μg/L was a good indication for cumulative live birth rate ( OR=1.916, 95% CI=1.115-3.290, P=0.008). Conclusion:For patients receiving IVF/ICSI treatment in an agonist long protocol, a higher prolactin level during controlled ovarian stimulation is positively associated with cumulative pregnancy/live birth rates.
