Research advances of T-cell inhibitory receptors in rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.01.031
- VernacularTitle:类风湿关节炎中T细胞抑制性受体的研究进展
- Author:
Chaoyue DIAO
1
;
Xinyu QIAN
;
Ning CHEN
;
Qian CHEN
;
Jie GAO
;
Dongbao ZHAO
Author Information
1. 海军军医大学第一附属医院风湿免疫科,上海 200433;海军第九七一医院内分泌科,青岛 266000
- Publication Type:Journal Article
- Keywords:
T cells;
Inhibitory receptors;
Co-inhibitory signaling pathway;
Rheumatoid arthritis;
Immune tolerance
- From:
Chinese Journal of Immunology
2025;41(1):202-208
- CountryChina
- Language:Chinese
-
Abstract:
T-cell inhibitory receptors(IR)are involved in the composing of co-inhibitory signaling pathways between T cells and immune cells,and transmit immunosuppressive signals to limit immune effects of T cells such as activation and proliferation.Ab-normal co-inhibitory signals may destroy the peripheral immune tolerance of the body,leading to hyperresponsiveness of various organ-specific autoimmunity.Rheumatoid arthritis(RA)is a complex systemic disease in which there is an immune disorder centered on T cells.In this process,the abnormal expression and distribution of T-cell IR are fully involved in the imbalance of T-cell subsets and pathological immune responses,affecting the development and progression of the disease.Targeting T-cell IR and its ligands and thus strengthening the co-inhibitory signaling pathway mediated by them has been studied for suppressing immune responses and maintain-ing immune tolerance,but their potential for clinical application in RA remains to be explored.In the present,we review the advances of T-cell IR involved in the immunopathology of RA,and discusses the therapeutic prospects of targeting these receptors.
