Research progress on animal models for the premature ovarian insufficiency
10.3760/cma.j.cn101441-20200809-00433
- VernacularTitle:卵巢功能不全动物模型的研究进展
- Author:
Zhen WANG
1
;
Lanlan FANG
1
;
Yingpu SUN
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Premature ovarian insufficiency;
Rodents;
Non-rodents;
Animal models
- From:
Chinese Journal of Reproduction and Contraception
2022;42(4):431-437
- CountryChina
- Language:Chinese
-
Abstract:
Premature ovarian insufficiency (POI) is a cause of infertility in women. It is characterized by menstrual disorders (such as menopause or sparse menstruation) with high gonadotropins and low estrogen levels in women younger than 40 years of age. Although some factors including ovarian surgery, chemotherapy, radiotherapy, chromosomal abnormalities or environmental have been reported to be involved in the development of POI, the underlying cause is not identified in the majority of cases. At present, there are mainly two kinds of POI animal models: rodent POI model and non-rodent POI model. Mouse POI model in rodent POI model has the most variety and mature method, and is most commonly used in POI related researches. Rat POI model is used less than mouse POI model, but it still has irreplaceable value for POI research. The ovarian morphology and oocytes of non-rodent POI model (rabbit, pig and non-human primate, etc.) can be easily observed, among which the non-human primate POI model is the most similar to human. However, due to the high experimental cost and strict feeding conditions, there is still little research on non-rodent POI model. Further research is needed to establish a complete model establishment system. This review summarized the established animal models for the POI which provides valuable information regarding the selection of suitable animal model for the research in the pathogenesis of POI.
