Dual role of USP11 in CRC anti-tumour immunity
10.3969/j.issn.1005-6483.20241279
- VernacularTitle:泛素特异性蛋白酶11在结直肠癌抗肿瘤免疫中的双重作用
- Author:
Yufei WU
1
;
Yan CHEN
1
;
Feng GUO
1
Author Information
1. 215001 苏州,南京医科大学附属苏州医院,苏州市立医院肿瘤内科
- Publication Type:Journal Article
- Keywords:
USP11;
colorectal cancer;
tumor microenvironment;
immune checkpoint in-hibitor
- From:
Journal of Clinical Surgery
2025;33(7):782-784
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer has a high incidence and mortality rate,and some patients do not benefit from existing treatments.Intestinal inflammation is one of the major risk factors for colorectal cancer,and an abnormal tumor immune microenvironment plays a crucial role in its occurrence and progression.As a deubiquitinating enzyme,USP11 stabilizes target proteins by removing ubiquitin molecules,thereby exerting dual roles in the antitumor immunity of colorectal cancer.USP11 enhances the specific recognition and cytotoxic function of T cells,promotes the differentiation and regulation of CD4+T cells,and induces macrophage polarization.Investigating the role and regulatory mechanisms of USP11 in colorectal cancer may provide new strategies and targets for its treatment.
