Role of TLR5 in pathogenesis of obesity-related hypertension:Current evidence and future challenges
10.3969/j.issn.1000-484X.2025.02.039
- VernacularTitle:TLR5在肥胖相关高血压发病机制中的作用:现有证据和未来挑战
- Author:
Ou WU
1
;
Xiaoxiao MI
;
Hu ZHANG
;
Chengda YUAN
;
Jin GAO
Author Information
1. 浙江树人学院树兰国际医学院,杭州 310015;浙江中医药大学,杭州 310053
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 5;
Hypertension;
Obesity;
Intestinal microbiota;
Immune tolerance
- From:
Chinese Journal of Immunology
2025;41(2):484-489
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptor 5(TLR5)is a pattern recognition receptor,the main extracellular receptor for recognizing flagel-lin,and a bridge between innate and adaptive immunity.It can activate innate immunity and induce the release of a series of down-stream cytokines,as well as play an important role in protecting the host from flagellated pathogens and establishing immune tolerance.These functions are related to the pathogenesis of obesity hypertension in various aspects.This article aims to review the relationship between TLR5 and obese hypertension,as well as the new progress on the interaction between TLR5 and flagellin structure and func-tion,and discuss the future research directions and challenges.
