Analysis of CT manifestations of tumor-like proliferation of extramedullary hematopoiesis in thalassemia
10.3969/j.issn.1002-1671.2025.08.022
- VernacularTitle:地中海贫血髓外造血组织瘤样增生的CT表现分析
- Author:
Yunqing WAN
1
;
Rongyong CHENG
;
Erjuan ZHANG
;
Yurong LIN
;
Hao ZHANG
;
Jinbang HUANG
Author Information
1. 德宏州人民医院医学影像科,云南 德宏 678400
- Publication Type:Journal Article
- Keywords:
thalassemia;
extramedullary hematopoiesis;
computed tomography
- From:
Journal of Practical Radiology
2025;41(8):1357-1360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the CT imaging manifestations of tumor-like proliferation of extramedullary hematopoiesis(EMH)in thalassemia(TM).Methods A retrospective analysis was conducted on the clinical data of 41 patients with tumor-like proliferation of EMH in TM.The CT imaging features of the patients were analyzed,including the location,lesion morphology,density,and degree of enhancement of the lesions.Results Lesions of varying sizes were identified on both sides of the thoracic vertebrae in all 41 cases,including 20 cases with lesions in the inner edge of the ribs and 1 case within the spinal epidural space.A total of 23 abdominal scans and 2 lumbar scans,lesions were found in the sacral region in 18 cases,primarily in the presacral area and sacral wings.Lesions adjacent to the thoracic paravertebral and in the sacral region were quasi-circular,while those on the ribs were quasi-circular or flat and mound-shaped,closely adhering to the inner edge of the ribs.Intraspinal epidural lesions were characterized by a longitudinal orientation,positioned adjacent to the posterior part of the thoracic spinal canal.Most lesions showed homogeneous moderate density.Bone erosion was observed in 14 rib lesions and 7 sacral region lesions,resulting in heterogeneous slightly high density shadow of the lesions.Small nodular high density shadow were identified in 4 cases,and small amounts of fatty density shadow were observed in 4 cases.20 cases showed mild-to-moderate enhancement on enhanced scan,and 11 cases showed"vascular traversal sign"in thoracic paravertebral lesions.Conclusion The CT manifestations of tumor-like proliferation of EMH in TM are characteristic.The combination of typical CT manifestations and medical history facilitates an accurate diagnosis.Indicators such as fat replacement,iron deposition nodules,bone erosion,and"vascular traversal sign"are valuable in the diagnosis of tumor-like proliferation of EMH.
