Rodent models of polycystic ovary syndrome
10.3760/cma.j.cn101441-20200508-00267
- VernacularTitle:多囊卵巢综合征的啮齿类动物模型
- Author:
Baoying LIAO
1
;
Xinyu QI
1
;
Jie QIAO
1
;
Yanli PANG
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心；国家妇产疾病临床医学研究中心（北京大学第三医院）；辅助生殖教育部重点实验室（北京大学）；北京市生殖内分泌与辅助生殖技术重点实验室；中国医学科学院卵成熟障碍综合诊治研究创新单元 100191
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Rodent model;
Metabolic abnormality;
Reproductive endocrine disorder;
Model methods
- From:
Chinese Journal of Reproduction and Contraception
2021;41(10):948-955
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of reproductive age. Its etiology is complex and its clinical heterogeneity is high. Metabolic abnormality is an important characteristic of PCOS and plays a crucial role in the pathogenesis of PCOS. This paper mainly reviews the reproductive endocrine disorders and metabolic abnormalities of rodent models induced by various modeling methods, discusses the applicable research of various models and provides a reference for the selection of PCOS rodent models, which matter in the etiology research and therapy exploration of PCOS.
