The relationship between fibrinogen to albumin ratio,PNI,SII index and prognosis of patients with lung cancer undergoing thoracoscopic surgery
10.3969/j.issn.1005-6483.20241362
- VernacularTitle:纤维蛋白原与白蛋白比值、预后营养指数、系统性免疫炎症指数与肺癌胸腔镜肺叶切除术病人预后关系的研究
- Author:
Lei NIU
1
;
Chengyu HUO
1
;
Zongzhi LIU
1
Author Information
1. 100022 北京,中国民航总医院外一科
- Publication Type:Journal Article
- Keywords:
fibrinogen to albumin ratio;
prognostic nutrition index;
systemic immune inflammation index;
lung cancer;
thoracoscopic surgery;
prognosis
- From:
Journal of Clinical Surgery
2025;33(7):708-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between fibrinogen to albumin ratio(FAR),prognostic nutritional index(PNI),systemic immune inflammation index(SII)and prognosis of patients with lung cancer undergoing thoracoscopic surgery.Methods The clinical data of 287 patients with lung cancer who underwent thoracoscopic lobectomy in the hospital from February 2018 to February 2020 were retrospectively collected.The FAR,PNI,and SII values were measured within one week before surgery.The 3-year survival after operation was counted.The relationship between clinical data,preoperative FAR,PNI,SII and 3-year survival prognosis was observed.The receiver operating characteristic curve(ROC)was used to determine the optimal cut-off values of preoperative FAR,PNI,and SII values for predicting the 3-year survival prognosis after surgery,and the prognostic value of single index and combination of each index was observed.Multivariate Logistic regression analysis was used to evaluate the influencing factors of prognosis.Pearson correlation analysis was used to explore the correlation between FAR,PNI and SII values.Results Finally,242 patients with lung cancer were included in the study,and 199 patients survived 3 years after operation,with an overall survival rate of 82.23％.43 cases(17.77％)died in 3 years.Age,serum carcinoembryonic antigen(CEA)level,lymph node metastasis,TNM stage,preoperative FAR,PNI and SII value were related to the 3-year survival prognosis of lung cancer patients after thoracoscopic lobectomy(P＜0.05).The ROC curve showed that the preoperative FAR,PNI and SII values had certain predictive value for the 3-year survival prognosis of patients after operation.The combined prediction of the three showed better predictive efficacy,and the area under the curve(AUC)was 0.772.Multivariate Logistic regression analysis showed that lymph node metastasis,TNM stage,FAR value and SII value were independent risk factors for postoperative survival and prognosis.PNI was an independent protective factor(P＜0.05).Pearson correlation analysis showed that there was a negative correlation between FAR and PNI,PNI and SII,and a positive correlation between FAR and SII(P＜0.05).Conclusion The values of FAR,PNI and SII are independently related to the prognosis of patients with lung cancer undergoing thoracoscopic surgery.The combined application has a higher prognostic value.
