Research progress of reversible inhibition of sperm under guidance male contraceptive needle
10.3760/cma.j.cn101441-20210218-00072
- VernacularTitle:RISUG男性避孕针研究进展
- Author:
Huang LIU
1
;
Xinzong ZHANG
1
Author Information
1. 国家卫生健康委男性生殖与遗传重点实验室，广东省生殖科学研究所，广东省生殖医院，广东省人类精子库，广州 510600
- Publication Type:Journal Article
- Keywords:
RISUG;
Contraception;
Male;
Progress
- From:
Chinese Journal of Reproduction and Contraception
2021;41(8):712-716
- CountryChina
- Language:Chinese
-
Abstract:
Since 1984, Indian medical experts reported that reversible inhibition of sperm under guidance (RISUG) had a good effect in male contraception, and was announced as a male contraceptive which could relieve female contraceptive pain, the international research on RISUG male contraceptive had been done nearly for 40 years. However, different studies had reported that the results were very different. Some scholars reported that the effect of the drug was not obvious, and some scholars reported that the side effects of the drug were too serious to be studied in depth. Therefore, the effectiveness and safety of the drug had always been the focus of debate, so its clinical progress was slow. In addition to the effect of the drug, its safety also needed to be further explored and analyzed. In this paper, the research background, action mechanism, experimental basis, research methods (including administration mode, administration and dose, onset time, action and effect, reversal mode and effect, safety evaluation, etc.), as well as the problems and development prospects of RISUG male contraceptive needle were reviewed.
