MRI diagnosis of ovarian granulosa cell tumor and fibrothecoma and relative clinical analysis
10.3969/j.issn.1002-1671.2025.08.018
- VernacularTitle:MRI对卵巢颗粒细胞瘤及纤维卵泡膜细胞瘤的鉴别诊断与相关临床分析
- Author:
Yi ZHANG
1
;
Jing ZHANG
;
Le LIU
Author Information
1. 西北妇女儿童医院医学影像中心,陕西 西安 710061
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
ovary;
granulosa cell tumor;
fibrothecoma
- From:
Journal of Practical Radiology
2025;41(8):1338-1342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of MRI in the differential diagnosis of ovarian granulosa cell tumor(OGCT)with fibrothecoma,and to analyze the clinical characteristics of the two diseases to improve the accuracy of preoperative diagnosis.Methods The clinical features and MRI findings of 20 cases of OGCT and 26 cases of fibrothecoma confirmed by surgery and pathology were analyzed retrospectively.Results 95％(19/20)of patients with OGCT had symptoms,and 54％(14/26)of patients with fibrothecoma had symptoms.There was a statistical difference between OGCT and fibrothecoma in the number of patients of symptoms and hormone-related symptoms.95％(19/20)of OGCT were unilateral lesions,and 5％(1/20)were bilateral lesions(21 lesions in total),which 67％(14/21)had regular edges and 33％(7/21)had irregular edges.The length of lesions ranged from 3.2 cm to 14.7 cm,with an average of(8.1±3.3)cm.Among them,38％(8/21)lesions were solid,33％(7/21)lesions were cystic,and 29％(6/21)lesions were solid with cystic masses.96％(25/26)of fibrothecoma were unilateral lesions and 4％(1/26)were bilateral lesions(27 lesions in total),which 59％(16/27)had regular edges and 41％(11/27)had irregular edges.The length of lesions ranged from 2.2 cm to 19.0 cm,with an average of(7.69±4.12)cm,which 89％(24/27)lesions were solid,7％(2/27)lesions were cystic,and 4％(1/27)lesions were solid with cystic masses.On T1 WI images,86％(18/21)of OGCT showed high signal,and 81％(17/21)lesions showed bleeding signal.100％(27/27)of fibrothecoma showed isointensity.On T2WI images,71％(15/21)of OGCT showed hyperintensity and 90％(19/21)lesions had multiple varies cysts.On T2WI images,63％(17/27)lesions of fibrothecoma showed hypointensity and 4％(1/27)lesion had honeycomb sign.There were no statistical differences in the location,shape and size of the lesions between the two groups.There were statistical differences in cystic-solid type,T,WI and T2WI signals,honeycomb signs and bleeding signals(P＜0.05).The mean apparent diffusion coefficient(ADC)value of OGCT was about(0.830±0.210)×10-3 mm2/s,and the mean ADC value of fibrothecoma was about(1.550±0.320)× 10-3 mm2/s,which had statistical difference.The critical value was 1.085 × 10-3 mm2/s of ADC value,which the sensitivity was 100％and the specificity was 90％.Conclusion The combination of clinical features,MRI signal characteristics and ADC value is helpful for the differential diagnosis of OGCT and fibrothecoma.
