Regulatory role of triggering receptor expressed on myeloid cells-1(TREM-1)in sepsis
10.3969/j.issn.1000-484X.2025.01.038
- VernacularTitle:髓源细胞表面触发受体1(TREM-1)在脓毒血症中的调控作用
- Author:
Hanlin LIU
1
;
Xin DAI
;
Qin LI
;
Wei WU
Author Information
1. 中国人民解放军西部战区总医院麻醉科,成都 610083
- Publication Type:Journal Article
- Keywords:
Sepsis;
Triggering receptor expressed on myeloid cells-1;
Immune;
Inflammation
- From:
Chinese Journal of Immunology
2025;41(1):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is an immune disorder caused by infection,which can lead to multiple organ dysfunction,immune response and immune cells play key role in the onset and progression of sepsis.As an immunoglobulin,triggering receptor expressed on mye-loid cells-1(TREM-1)has immunomodulatory effects and participates in the pathophysiological process of many diseases.TREM-1 can regulate inflammatory mediators and immune cells in sepsis,playing an important role in its diagnosis,treatment and prognosis.This article summarizes the role and possible mechanism of TREM-1 in occurrence and development of sepsis,and provides a theoreti-cal basis for the research direction and treatment strategy of the disease.
