Research progress of sex hormone and allergic diseases
10.3969/j.issn.1000-484X.2025.01.034
- VernacularTitle:性激素和过敏性疾病的研究进展
- Author:
Xinyi SONG
1
;
Hanye LIU
1
;
Dandan WANG
1
;
Hongyu JIN
1
;
Guanghai YAN
1
;
Liangchang LI
1
Author Information
1. 吉林省过敏性常见疾病免疫与靶向研究重点实验室,延吉 133002
- Publication Type:Journal Article
- Keywords:
Allergic disease;
Sex hormone;
Estrogens;
Estradiol;
Progesterone;
Androgen
- From:
Chinese Journal of Immunology
2025;41(1):220-225
- CountryChina
- Language:Chinese
-
Abstract:
Nowadays,the incidence of allergic diseases is increasing worldwide,which seriously affects the quality of human life.Recent studies have shown that sex hormones are closely related to the occurrence of allergic diseases.Sex hormones can directly affect the function and development of immune cells,as well as the susceptibility to autoimmune cell responses,resulting in different prevalence and clinical manifestations of allergic diseases in men and women.This article reviews the different roles and potential mechanisms of sex hormones in the occurrence and development of common allergic diseases.In atopic dermatitis,the amount of dehy-droepiandrosterone sulfate into dehydroepiandrosterone sulfate is higher in females than in males.Therefore,females are more suscep-tible to the influence of dehydroepiandrosterone,which inhibits the proliferation of Th2,resulting in a series of clinical symptoms.In allergic asthma,estrogen can aggravate type 2 airway inflammation and androgens can reduce type 2 airway inflammation.Studies have found that there are estrogen and progesterone receptors in the nasal mucosa.When the estrogen concentration increases,the two re-ceptors are also up-regulated,resulting in clinical manifestations such as increased nasal secretions and nasal mucosal swelling.
