The effect of low-frequency repetitive transcranial magnetic stimulation combined with unilateral upper limb mirror training on contralateral limb strength in patients with hemiplegia after ischemic stroke
10.3969/j.issn.1002-1671.2025.08.002
- VernacularTitle:低频重复经颅磁刺激结合单侧上肢镜像训练对缺血性脑卒中后偏瘫患者对侧肢体力量的影响
- Author:
Yan LI
1
;
Bing WANG
1
;
Qiuju CHEN
1
;
Zhenyuan LIU
1
;
Wenqi ZHANG
1
Author Information
1. 衡水市人民医院 哈励逊国际和平医院康复医学科,河北 衡水 053000
- Publication Type:Journal Article
- Keywords:
hemiplegia after ischemic stroke;
low-frequency repetitive transcranial magnetic stimulation;
mirror training;
limb strength
- From:
Journal of Practical Radiology
2025;41(8):1262-1266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of low-frequency repetitive transcranial magnetic stimulation(rTMS)combined with unilateral upper limb mirror training on contralateral limb strength in patients with hemiplegia after ischemic stroke.Methods A total of 196 patients with hemiplegia after ischemic stroke were selected.All patients were divided into study group and control group via a random number table method,with 98 patients in each group.The control group received mirror training,while the study group received low-frequency rTMS treatment in addition to the control group.The neuroelectrophysiology,neurological function,limb motor function,and clinical efficacy of all patients were observed before and after treatment,and all patients were performed the resting-state functional MRI examination.A generalized estimating equation(GEE)model were used to analyze the improvement of contralateral limb strength.Results After treatment,the seed points in the study group showed a significant enhancement in connectivity with the whole brain function.The overall efficiency of the study group was significantly better than that of the control group.After treatment,the central motor conduction time(CMCT),neuron specific enolase(NSE),cortical latency(CL),and S100β of the two groups of patients were significantly reduced compared with before treatment,while the neurotrophin-3(NT-3),nerve growth factor(NGF),Fugl-Meyer assessment upper extremities(FMA-UE),Wolf motor function test(WMFT),modified Barthel index(MBI),and Berg balance scale(BBS)scores were significantly increased.Moreover,the study group showed a more significant improvement compared to the control group(P＜0.05).The GEE model analysis results showed that the improvement of contralateral limb strength in the study group was significantly better than that in the control group.Conclusion Low-frequency rTMS combined with unilateral upper limb mirror training can improve cortical excitability and upper limb motor function in hemiplegic patients after ischemic stroke,with good therapeutic effects.
