Mechanism and function of human leucocyte antigen G at the interface of maternal-fetal tolerance

VernacularTitle:人类白细胞抗原-G在母-胎免疫界面的功能和作用机制
Author: Jin SHANG ¹ ; Baimei ZHUANG ; Yuanqing YAO
Author Information

1. 中国人民解放军总医院研究生院，北京　100853
Publication Type:Journal Article
Keywords: Human leukocyte antigen G; Maternal-fetal interface; Maternal-fetal immunologic toleration; Extravillous trophoblast
From: Chinese Journal of Reproduction and Contraception 2022;42(4):407-412
CountryChina
Language:Chinese
Abstract: Human leukocyte antigen G (HLA-G), one of the non-classical major histocompatibility complex class I molecules, is expressed uniquely on the extravillous trophoblast (EVT) cells at the maternal-fetal interface. Semi-allogeneic fetal EVT cells invade into the decidua during pregnancy without maternal immune cell attack, among which HLA-G plays an extremely important role. The special immune regulatory mechanisms of HLA-G at the interface of maternal-fetal tolerance, especially the possible molecular mechanisms interaction with immune cells and its membrane surface receptors, has been reentered into researchers' field. This review focuses on the expression, regulatory mechanisms and function related immune cells of HLA-G in the interface of maternal-fetal.