Research progress on the relationship between circular RNA and polycystic ovary syndrome
10.3760/cma.j.cn101441-20201111-00616
- VernacularTitle:环状RNA与多囊卵巢综合征关系的研究进展
- Author:
Qiuyun ZHENG
1
;
Zhaoqi LIU
;
Zhiying LI
Author Information
1. 三峡大学附属仁和医院妇产科，宜昌 443001
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Circular RNA;
Granulosa cells;
Ovulation disorders
- From:
Chinese Journal of Reproduction and Contraception
2021;41(8):759-763
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common clinical reproductive endocrine disease, and its incidence is increasing year by year. The occurrence and development of PCOS are related to many factors, among which genetic factors may play a key role. Circular RNA (circRNA) is a new type of universal and diverse endogenous non-coding RNA. The 3' and 5' ends of circRNA can be covalently linked together, causing it to form a circular structure. In addition, circRNA can resist degradation and maintain a high degree of stability under the mediation of RNA exonuclease. CircRNA also has cell specificity, tissue specificity and timing specificity. Compared with microRNA, circRNA is a more ideal disease biomarker, providing a new target for subsequent treatment of various diseases. An increasing number of studies have shown that circRNA is related to the pathophysiology of PCOS, and plays a role in endocrine hormone secretion, follicle development, granulosa cell proliferation and apoptosis, and genetic tendency, and participates in each link of the occurrence and development of PCOS. This article reviews the research reports on the relationship between circRNA and PCOS in recent years, hoping to provide new ideas for the diagnosis and treatment of PCOS.
