Correlation analysis of cuprotosis-related gene DLD expression,prognosis and its immune infiltration in pan-cancer
10.3969/j.issn.1000-484X.2025.01.021
- VernacularTitle:铜死亡相关基因DLD在泛癌中的表达及其与预后、免疫浸润的相关性分析
- Author:
Chunbo YU
1
;
Yu ZHOU
;
Dayu LI
;
Xianlin XU
;
Changfu LI
;
Fang FAN
Author Information
1. 遵义医科大学基础医学院生物化学教研室,遵义 563000
- Publication Type:Journal Article
- Keywords:
DLD;
Pan-cancer;
Immune infiltration;
Tumor microenvironment;
Bioinformatics
- From:
Chinese Journal of Immunology
2025;41(1):144-152,中插3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between cuprotosis-realted gene DLD expression in pan-cancer and progno-sis,tumor microenvironment and tumor immune infiltration by bioinformatics methods combined with multiple databases.Methods:TCGA,GTEx,TISDB,GEO,UCSC,TARGET,TIMER2.0,GEPIA2,SangerBox,PrognoScan and related R software packages were used to analyze the difference of DLD expression between human cancer and adjacent normal tissues,inestigate relationship between prognosis,explore expression of DLD in different immune subtypes and molecular subtypes of human cancer,analyze correlation between DLD expression and tumor immune infiltration and tumor microenvironment,detecet relationship between DLD expression and 60 immune checkpoint genes.Results:There were differences in expression of DLD in different tumor tissues;low DLD expression in 6 tumors and high DLD expression in 3 tumors were significantly associated with better prognosis;15 tumor immune subtypes,11 molecular subtypes of tumors were significantly correlated with DLD expression;DLD expression was significantly correlated with immune infiltration in 37 cancer types;DLD expression was significantly associated with immune infiltration in 23 tumor stroma scores,26 tumor immune scores and 25 tumor ESTIMATE scores;60 immune checkpoint genes in 39 tumors were significantly associated with DLD expression.Conclusion:Expression of DLD in pan-cancer is related to tumor prognosis and immune invasion,DLD may be a potential predictor of prognosis in tumors,and may be an immunomodulator of tumors.
