Analysis of the status quo and influencing factors of compliance with prolonged endocrine therapy in hormone receptor-positive breast cancer patients
10.3969/j.issn.1005-6483.20241737
- VernacularTitle:激素受体阳性型乳腺癌病人延长内分泌治疗依从性的现状及影响因素分析
- Author:
Lijing NIE
1
;
Lu GAN
1
;
Yunyun CHEN
1
;
Xiaojing DONG
1
;
Shuai LI
1
;
Yiming MIAO
1
;
Nan ZHANG
1
Author Information
1. 200025 上海,上海交通大学医学院附属瑞金医院乳腺疾病诊治中心
- Publication Type:Journal Article
- Keywords:
breast cancer;
extended endocrine therapy;
treatment adher-ence;
influencing factors
- From:
Journal of Clinical Surgery
2025;33(7):717-721
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the compliance of hormone receptor-positive breast cancer patients with prolonged endocrine therapy and analyze its influencing factors.Methods This study was a retrospective cohort study.A total of 347 patients with breast cancer who received prolonged endocrine therapy in our hospital from June 2017 to March 2023 were selected.Relevant data of the patients were collected and they were divided into two groups according to whether they adhered to prolonged endocrine therapy:the compliance group and the non-compliance group.Using the x2 test to analyze the impact of patients'disease-related data on prolonging compliance with endocrine therapy.Use Logistic regression to analyze its influencing factors.Results Among 347 breast cancer patients who received extended endocrine therapy,during the median follow-up of 28 months(ranging from 12 to 60 months),319 patients(91.9％)adhered to extended endocrine therapy(compliance group),and their treatment compliance was acceptable.Twenty-eight cases(8.1％)of patients did not adhere to prolonged endocrine therapy(non-compliance group).Multivariate analysis showed that the independent factors Influencing the compliance of breast cancer patients with prolonged endocrine therapy were comorbidities and radiotherapy(P＜0.05).Conclusion Based on the characteristics of influencing factors,behavioral interventions such as increasing follow-up frequency and strengthening health education content can be implemented for some patients without comorbidities and those who have not received radiation therapy,and to improve treatment compliance.
