Role of ubiquitin-proteasome system in spermatogenesis and fertilization
10.3760/cma.j.cn101441-20201112-00617
- VernacularTitle:泛素-蛋白酶体系统在精子发生及受精过程中的作用
- Author:
Fangyu WANG
1
;
Xiaopan CHEN
;
Chenglu WANG
;
Jing SHU
Author Information
1. 蚌埠医学院 233000
- Publication Type:Journal Article
- Keywords:
Ubiquitin-proteasome system;
Ubiquitination;
Spermatogenesis;
Fertilization;
Infertility
- From:
Chinese Journal of Reproduction and Contraception
2021;41(6):562-567
- CountryChina
- Language:Chinese
-
Abstract:
The ubiquitin-proteasome system (UPS) is a protein degradation system in addition to lysosomal system in eukaryotic cells. UPS can eliminate misfolded proteins and reduce the occurrence of aging diseases caused by the accumulation of misfolded proteins. The selective protein degradation of UPS acts on the mitosis and meiosis process of spermatogonia, which is very important for spermatogenesis. In addition, important reproductive processes such as sperm capacitation, acrosome reaction, penetrating zona pellucida and elimination of sperm mitochondria after fertilization are also closely related to UPS. This article reviews the recent literatures on the role of UPS in spermatogenesis, fertilization and its relationship with infertility.
