Research progress on immune regulation and clinical treatment strategies in respiratory viral infections
10.3969/j.issn.1000-484X.2025.01.036
- VernacularTitle:呼吸道病毒感染中的免疫调节及临床治疗策略研究进展
- Author:
Tao LIU
1
;
Tianyuan ZHANG
1
;
Lin MA
1
;
Qianru ZHAO
1
;
Junhua ZHANG
1
;
Yu WANG
1
;
Lu CHEN
1
;
Han ZHANG
1
Author Information
1. 天津中医药大学中医药研究院,天津 301617
- Publication Type:Journal Article
- Keywords:
Immune regulation;
Innate immunity;
Adaptive immunity;
Clinical treatment strategies;
Respiratory viral infec-tions
- From:
Chinese Journal of Immunology
2025;41(1):231-240,245
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory viral infections such as influenza and respiratory syncytial virus infections continue to rapidly increase in patients worldwide.Host immune responses to respiratory viruses play a key role in the pathogenesis and clinical manifestations of the disease.Respiratory viruses not only activate antiviral immune responses,but also may lead to uncontrolled inflammatory re-sponses,characterized by significant release of pro-inflammatory cytokines in severely infected patients,resulting in lymphopenia,lymphocyte dysfunction,and abnormalities in immune cells such as neutrophils and macrophages.These respiratory virus-induced im-mune abnormalities may lead to microbial infection,septic shock,and severe multiorgan dysfunction.Therefore,clarifying the immu-nopathogenic mechanisms of patients with respiratory viral infections can guide clinical treatment and patient prognosis;in addition,rational regulation of the immune response of respiratory viruses in the host,including enhancing antiviral immunity while suppressing systemic inflammation,may be the key to successful treatment.This review mainly discusses the immunomodulation and related clini-cal treatment strategies for respiratory viral infections to help develop new therapeutic strategies for respiratory viral infections and pa-tient prognosis.
