Relationship between sleep quality,serum S100 calcium-binding protein β subunit level,soluble CD40 ligand level and the severity of cerebral small vessel disease
10.3969/j.issn.1004-1648.2025.04.002
- VernacularTitle:睡眠质量及血清S100钙结合蛋白β亚单位、可溶性CD40配体水平与脑小血管病病情严重程度的关系
- Author:
Mingjia LU
1
;
Ting ZHONG
1
;
Meng DONG
1
Author Information
1. 830001 乌鲁木齐,新疆维吾尔自治区人民医院神经内科(新疆脑卒中与神经系统罕见病临床医学中心)
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
sleep quality;
S100 calcium-binding protein β subunit;
soluble CD40 ligand;
disease severity
- From:
Journal of Clinical Neurology
2025;38(4):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between sleep quality,serum S100 calcium-binding proteinβ subunit(S100β)level,soluble CD40 ligand(sCD40L)level and the severity of cerebral small vessel disease.Methods According to the total imaging load score,60 cerebral small vessel disease patients were divided into severe disease group(22 cases)and mild-to-moderate disease group(38 cases).The general clinical data,Pittsburgh sleep quality index(PSQI),Epworth sleepiness scale(ESS)score,insomnia severity index(ISI)score and the levels of S100β and sCD40L were compared between the two groups.Binary Logistic regression analysis was used to evaluate the correlation between the difference index between the groups and the severity of the disease in patients with cerebral small vessel disease.Results The rate of hypertension in severe disease group was significantly higher than that in mild-to-moderate disease group(P＜0.05).The ESS and ISI scores in severe disease group were significantly higher than those in mild-to-moderate disease group(all P＜0.001).The levels of serum S100β and sCD40L in severe disease group were significantly higher than those in mild-to-moderate disease group(all P＜0.001).Univariate Logistic regression analysis showed that hypertension,ESS score,ISI score,S100β level and sCD40L level were potentially correlated with the severity of cerebral small vessel disease(all P＜0.05).Multivariate Logistic regression analysis showed that ESS score,ISI score,S100β level and sCD40L level were closely related to the severity of cerebral small vessel disease(all P＜0.05).Conclusions The severity of sleepiness and insomnia and the levels of serum S100β and sCD40L in patients with cerebral small vessel disease are closely related to the severity of the disease.Paying attention to the sleep status and the body's inflammatory state of patients is conducive to a more accurate assessment of the severity of cerebral small vessel disease.
