Correlation between ADGRG5 expression and clinical prognosis and immune response in pancreatic adenocarcinoma
10.3969/j.issn.1000-484X.2025.01.023
- VernacularTitle:胰腺癌中ADGRG5表达与临床预后及肿瘤免疫应答的关系
- Author:
Jiangming ZHONG
1
;
Deyu LI
1
;
Guifeng ZHANG
1
;
Qiao CHEN
1
;
Li LIN
1
;
Zhenhua LIU
1
Author Information
1. 福建省立医院肿瘤内科,福州 350001
- Publication Type:Journal Article
- Keywords:
Pancreatic adenocarcinoma;
ADGRG5;
Diagnosis;
Prognosis;
Immune infiltration
- From:
Chinese Journal of Immunology
2025;41(1):157-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate relationship between expression of ADGRG5 and clinical prognosis and immune response in pancreatic adenocarcinoma(PAAD).Methods:ADGRG5 expression in PAAD and normal tissues were compared by Wilcoxon rank sum test.Diagnostic value of ADGRG5 was evaluated by ROC curve in PAAD.Kaplan-Meier method and Cox regres-sion analysis were used to evaluate prognostic factors.Gene set enrichment analysis(GSEA)and immune infiltration analysis were applied to annotate biological function of ADGRG5.Results:ADGRG5 expression in PAAD was significantly higher than normal tissue(P=2.8e-32).ADGRG5 had significant diagnostic and prognostic ability for PAAD(AUC=0.866).High ADGRG5 expression predicted a good progress free interval(PFI)(P=0.01),and expression of ADGRG5 was independently associated with PFI(HR:0.656,95%CI:0.433～0.972,P=0.035).ADGRG5 expression was related to regulation of immunomodulatory pathway and function of some types of immune infiltrating cells.Conclusion:Increased ADGRG5 may be a potential biomarker for PAAD diagnosis and prognosis,which affects prognosis of PAAD patients and significantly correlated with immune infiltration.
