Exploration of relationship between IL-17/IL-23 immunoinflammatory axis and chronic heart failure and clinical prognosis
10.3969/j.issn.1000-484X.2025.01.022
- VernacularTitle:IL-17/IL-23免疫炎症轴与慢性心力衰竭及临床预后的关系探究
- Author:
Mingyan CHENG
1
;
Jinghua WANG
;
Wenyue WANG
;
Na TIAN
;
Yanfei GAO
;
Yanchun WANG
;
Tao YANG
Author Information
1. 承德市中心医院检验科,承德 067000
- Publication Type:Journal Article
- Keywords:
Chronic heart failure;
IL-17/IL-23;
Immunoinflammatory axis;
Clinical prognosis
- From:
Chinese Journal of Immunology
2025;41(1):153-156,162
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate relationship between IL-17/IL-23 immunoinflammatory axis and chronic heart failure(CHF)and clinical prognosis.Methods:A total of 112 patients with CHF in Chengde Central Hospital from January 2020 to Septem-ber 2021 were selected as observation group,and another 112 patients admitted to same period for healthy physical examination were selected as control group.Serum IL-17 and IL-23 levels of two groups were compared,relationship between serum IL-17 and IL-23 levels and degree of disease were analyzed;clinical data,serum IL-17 and IL-23 levels of patients with different prognosis were compared,relationship between serum IL-17 and IL-23 levels and clinical prognosis of CHF patients were analyzed.Predictive value of serum IL-17 and IL-23 levels on clinical prognosis of CHF patients was evaluated,and predictive value of each prediction scheme was compared.Results:Serum IL-17 and IL-23 levels were higher in observation group than control group(P<0.05);serum IL-17 and IL-23 levels of CHF patients were positively correlated with NYHA classification(P<0.05).Serum IL-17 and IL-23 levels were higher in patients with poor prognosis than in those with good prognosis(P<0.05).Serum IL-17 and IL-23 were independently associated with clinical prognosis of CHF patients,and the higher the serum IL-17 and IL-23 levels,the greater risk of poor clinical prognosis of CHF patients.AUC of serum IL-17 and IL-23 levels for predicting clinical prognosis of CHF patients were 0.787 and 0.726,respectively,and combined predicted AUC was 0.918(P<0.001);combined predicted AUC of serum IL-17 and IL-23 was significantly higher than single index(P<0.05).Conclusion:IL-17 and IL-23 levels in IL-17/IL-23 immunoinflammatory axis of CHF patients are significantly elevated and involve in disease occurence and development,whose clinical detection can help predict clinical prognosis of CHF.
