Analysis on related genes and immune cell infiltration characteristics in hypertrophic cardiomyopathy based on bioinformatics
10.3969/j.issn.1000-484X.2025.01.025
- VernacularTitle:基于生物信息学分析肥厚型心肌病相关基因及免疫细胞浸润特征
- Author:
Fuyu YIN
1
;
Lijun ZHANG
1
Author Information
1. 武汉大学人民医院老年病科,武汉 430060
- Publication Type:Journal Article
- Keywords:
Hypertrophic cardiomyopathy;
Biomarkers;
Immune infiltration;
Bioinformatics
- From:
Chinese Journal of Immunology
2025;41(1):169-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Screening of hypertrophic cardiomyopathy-related signature genes and analysis of immune cell infiltra-tion characteristics by bioinformatics methods.Methods:The dataset was downloaded from the GEO database,and multiple algo-rithms in R language were used to analyze differentially expressed genes,construct weighted gene co-expression networks to obtain clinical relevance module,screen core genes,identify signature genes,identify signature gene prognosis efficacy and perform func-tional enrichment to explore immune cell infiltration.Results:A total of 117 differential genes and a core module containing 32 genes were screened,and 19 core genes were obtained.Among them,ABCA5,DNAJC16,LGALS14,MGAT4A,SLC30A8 were identified as signature genes.Statistically significant changes in the levels of macrophages,eosinophils,and plasmacytoid dendritic cells in the plasma of patients with hypertrophic cardiomyopathy compared with healthy controls were observed(P<0.05).Conclusion:The char-acteristic genes ABCA5,DNAJC16,LGALS14,MGAT4A and SLC30A8 may serve as prognosis markers for hypertrophic cardiomyop-athy,immune cells such as macrophages and eosinophils may be involved in the occurrence and development of hypertrophic cardio-myopathy.
