Effect of inflammatory cytokines on follicular development
10.3760/cma.j.cn101441-20200320-00145
- VernacularTitle:炎症因子对卵泡发育的影响
- Author:
Wenjie ZHANG
1
;
Jiayi SONG
1
;
Zhen DOU
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院 300193
- Publication Type:Journal Article
- Keywords:
Inflammation;
Cytokines;
Ovarian follicle;
Growth;
Development
- From:
Chinese Journal of Reproduction and Contraception
2021;41(4):377-381
- CountryChina
- Language:Chinese
-
Abstract:
The physiological inflammatory response mediated by inflammatory cytokines such as interleukin (IL)-1 family, IL-6, tumor necrosis factor (TNF)-α, granulocyte macrophage colony stimulating factor (GM-CSF) is involved in follicular development, maturation and ovulation. The abnormal expression of inflammatory cytokines causes pathological inflammatory response, which can lead to ovulation disorders and infertility, was mainly observed in polycystic ovary syndrome (PCOS), endometriosis (EMS), premature ovarian insufficiency (POI), obesity, hypothyroidism and other diseases. This paper focuses on the physiological effect of inflammatory cytokines on follicular development and the possible mechanism of affecting the development of oocytes in different diseases, in order to provide help for the diagnosis and treatment of ovulatory dysfunctional infertility.
