The Relationship Between Plasma Big Endothelin-1 Level and Left Ventricular Remodeling Assessed by Cardiac Magnetic Resonance in Patients With Hypertrophic Obstructive Cardiomyopathy
10.3969/j.issn.1000-3614.2025.01.007
- VernacularTitle:肥厚型梗阻性心肌病患者血浆大内皮素-1水平与心脏磁共振成像左心室重构的相关性研究
- Author:
Youzhou CHEN
1
;
Wenlan HU
;
Jihong WANG
;
Shubin QIAO
;
Wei LIU
Author Information
1. 首都医科大学附属北京积水潭医院 心血管内科,北京 100035
- Publication Type:Journal Article
- Keywords:
hypertrophic obstructive cardiomyopathy;
left ventricular remodeling;
late gadolinium enhancement;
big endothelin-1;
myocardial fibrosis
- From:
Chinese Circulation Journal
2025;40(1):63-68
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the relationship between plasma big endothelin-1(Big ET-1)level and left ventricular(LV)remodeling assessed by cardiac magnetic resonance(CMR)in patients with hypertrophic obstructive cardiomyopathy(HOCM).Methods:A total of 180 consecutive HOCM patients were enrolled from November 2013 to July 2015 in Fuwai Hospital,Chinese Academy of Medical Sciences.The baseline characteristics of the patients were collected and the plasma Big ET-1 levels were measured.According to LV remodeling index(LVRI),the patients were divided into severe remodeling group(LVRI>1.3 g/ml,n=119)and mild remodeling group(LVRI≤1.3 g/ml,n=61).The Pearson correlation analysis and multivariate logistic regression analysis were conducted to assess the correlations between plasma Big ET-1 level and indicators of LV remodeling.Results:Compared to the mild remodeling group,the plasma Big ET-1 level([0.84±0.30]pmol/L vs.[0.41±0.19]pmol/L),LVRI([1.7±0.3]g/ml vs.[1.1±0.1]g/ml),the extent of late gadolinium enhancement(LGE)([16.8±8.9]g vs.[7.0±6.6]g)were significantly higher in the severe remodeling group(all P<0.001).Pearson correlation analysis revealed that in patients with HOCM,plasma Big ET-1 level were positively correlated with left atrial anteroposterior diameter,interventricular septal thickness(IVS),LV mass(LVM),LVRI,LGE and LV outflow tract(LVOT)gradient and negatively correlated with LV ejection fraction(all P<0.05).Multivariate logistic regression analysis showed that LVM(OR=1.037,95% CI:1.019-1.056,P<0.001)and plasm Big ET-1 level(OR=11.461,95% CI:2.264-58.014,P=0.003)were the independent determinants for severe LV remodeling in HOCM patients.Conclusions:Among patients with HOCM,the plasma Big ET-1 level are markedly higher in those with severe LV remodeling and are positively associated with left atrial anteroposterior diameter,IVS,LVRI,LVM,LVOT gradient and LGE.Elevated Big ET-1 level and LVM are independent determinants of severe LV remodeling in HOCM patients.
