Research progress on the relationship between abnormal DNA methylation and recurrent spontaneous abortion
10.3760/cma.j.cn101441-20200312-00127
- VernacularTitle:异常DNA甲基化与复发性流产关系的研究进展
- Author:
Yunlu PING
1
;
Sha JIANG
;
Xiaoxuan ZHAO
;
Xiaoling FENG
Author Information
1. 黑龙江中医药大学，哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Epigenetics;
DNA methylation;
Recurrent spontaneous abortion;
Embryonic development
- From:
Chinese Journal of Reproduction and Contraception
2021;41(4):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Recurrent spontaneous abortion (RSA) is a common disease in women of reproductive age, and the pathogenesis is not fully understood. In recent years, with in-depth research in the field of epigenetics, DNA methylation has gradually become a new perspective on the pathophysiology of RSA. Studies have shown that the regulation of DNA methylation modification is closely related to RSA. Abnormal DNA methylation and its imprinting disorders, dysregulated gene expression disorders, sperm defects and immune system abnormalities directly or indirectly affect embryo implantation. The growth and development process eventually lead to the occurrence of RSA. The role of DNA methylation in the pathogenesis of RSA and its regulatory pathways are reviewed.
