Serum Level and Clinical Implication of Secreted Frizzled-related Protein 4 in Peripheral Blood of Patients With Dilated Cardiomyopathy
10.3969/j.issn.1000-3614.2025.01.006
- VernacularTitle:扩张型心肌病患者的血清分泌型卷曲相关蛋白4水平及其临床预后预测价值分析
- Author:
Yucheng WANG
1
;
Ying YU
;
Hui SHI
;
Yong YU
;
Ruizhen CHEN
Author Information
1. 复旦大学附属中山医院 心内科 上海市心血管病研究所,上海 200032
- Publication Type:Journal Article
- Keywords:
dilated cardiomyopathy;
secreted frizzled-related protein 4;
all-cause mortality;
prognosis prediction
- From:
Chinese Circulation Journal
2025;40(1):54-62
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the expression and clinical prognostic implication of secreted frizzled-related protein 4(SFRP4)in the peripheral blood of patients with dilated cardiomyopathy(DCM)and its.Methods:A total of 259 consecutive patients diagnosed with DCM who were admitted to the Cardiac Center of Zhongshan Hospital,Fudan University,from January 2017 to January 2019 were selected for the DCM group.Additionally,84 individuals who underwent health examinations and echocardiography at our hospital during this period,confirmed to be free of cardiovascular diseases,were selected as the control group.Peripheral serum samples were collected from both groups,and serum SFRP4 levels were measured using enzyme-linked immunosorbent assay(ELISA).The correlation between SFRP4 levels and DCM severity,as well as its predictive value for DCM prognosis,were analyzed.Results:Compared to the control group,the serum SFRP4 levels in the DCM group were significantly elevated([28.54±10.25]ng/ml vs.[52.70±19.74]ng/ml,P<0.05).The DCM group was randomly divided into a training set and a validation set in a 2:1 ratio.Multivariate logistic regression analysis in the training set revealed that serum SFRP4 levels were independently associated with all-cause mortality in DCM patients(OR=1.06,95% CI:1.03-1.10,P<0.001).We further evaluated the model's predictive performance with the receiver operating characteristic(ROC)curves(area under curve>0.8),calibration curves,and decision curve analysis,results indicated that the predictive model containing serum SFRP4 levels showed good performance on predicting all-cause mortality in DCM patients.Kaplan-Meier survival curve analysis demonstrated that during a median follow-up of 33.5(11.0,49.0)months,DCM patients with high peripheral blood SFRP4 levels(≥75th percentile)had a significantly higher incidence of all-cause mortality compared to those with low levels(<75th percentile)(28.81% vs.16.57%,P=0.02).Conclusions:The level of SFRP4 in the peripheral blood of DCM patients is significantly elevated,and peripheral serum SFRP4 levels have potential prognostic value for predicting the all-cause mortality in DCM patients.
