Effect of lipid metabolism on endometrial receptivity
10.3760/cma.j.cn101441-20200929-00540
- VernacularTitle:脂代谢对子宫内膜容受性的影响
- Author:
Yunying LIN
1
;
Yun SUN
1
Author Information
1. 上海交通大学医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室 200135
- Publication Type:Journal Article
- Keywords:
Endometrial receptivity;
Lipid metabolism;
Prostaglandins;
Lysophosphatidic acid;
Endocannabinoids
- From:
Chinese Journal of Reproduction and Contraception
2021;41(5):402-407
- CountryChina
- Language:Chinese
-
Abstract:
Repeated implantation failure is currently one of the most difficult problems in reproductive medicine, and impaired endometrial receptivity plays an important role in repeated implantation failure. In recent years, with the development of lipidomics and metabolomics, it has been found that the endometrial receptivity can be affected by the regulation of lipid metabolism, and it is hypothesized that prostaglandins may be the intersection of the underlying mechanism. Enhancing the understanding of endometrial lipid metabolism helps to determine the exact time for embryo transfer and reduce the rate of implantation failure. In this article, we systematically review the effects of phospholipid metabolites, cholesterol and fat metabolism on endometrial receptivity, providing new ideas for predicting and improving endometrial receptivity.
