The relationship between interventricular septal dimensions and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.08.001
- VernacularTitle:2型糖尿病患者舒张末期室间隔厚度与尿白蛋白/肌酐比值相关性的研究
- Author:
Lijuan WANG
1
;
Shengnan LIU
;
Hongmei MA
;
Zhenya WU
;
Fanfan LI
;
Jingjuan LI
;
Ruifei YANG
;
Yuanyuan LIU
;
Jinyang WANG
Author Information
1. 730000 兰州,甘肃中医药大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Interventricular septal dimensions;
Urinary albumin/creatinine ratio
- From:
Chinese Journal of Diabetes
2025;33(8):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between interventricular septal dimensions(IVSd)and urinary albumin/creatinine ratio(UACR)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 757 patients with T2DM hospitalized in the Department of Endocrinology of Gansu Provincial People's Hospital from March 2021 to April 2024 were enrolled in this study.All the patients were divided into T2DM patients without proteinuria(n=388),microproteinuria group(Mic,n=260)and macroproteinuria group(Mac,n=109)according to the UACR levels.General clinical data and biochemical indexes were collected from all the patients.Color Doppler echocardiography was used to record left ventricular ejection fraction(LVEF),left ventricular fraction shortening(LVFS),IVSd,left ventricular posterior wall dimensions(LVPWd),and left atrial diameter(LAD).Pearson correlation analysis was conducted to analyze the correlation between IVSd,LVPWd and related indicators of renal function.Logistic regression analysis was conducted to analyze the influencing factors for T2DM patients with proteinuria.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of the DM duration and IVSd in patients with T2DM and proteinuria.Results The DM duration,SBP,FIns,HbA1c,Scr,24 hUTP,UACR,UAER,IVSd,LVPWd were increased successively(P<0.05),while LVEF and eGFR were decreased successively(P<0.05)in T2DM,Mic,Mac group.Age was higher in Mic group than in T2DM group(P<0.05).DBP and FPG were higher in Mac group than in T2DM and Mic group(P<0.05).Pearson correlation analysis showed that IVSd and LVPWd were positively correlated with 24 hUTP,UACR,UAER and Scr(P<0.05),and negatively correlated with eGFR(P<0.05).Logistic regression analysis indicated that the DM duration and IVSd were significant influencing factors for proteinuria in patients with T2DM.ROC curve showed that the area under ROC curve of IVSd was 0.620,with sensitivity 43.3%and specificity 76.8%,respeictively.Conclusions The DM duration and IVSd are influencing factors for UACR in patients with T2DM.The risk of proteinuria in T2DM patients increases with rising IVSd.
