Diabetic ketoacidosis caused by dapagliflozin
10.3760/cma.j.cn114015-20220610-00516
- VernacularTitle:达格列净致糖尿病酮症酸中毒
- Author:
Xiaofeng WANG
1
;
Jing LIU
;
Chang LIU
;
Zhong XIN
Author Information
1. 内蒙古锡林郭勒盟蒙医医院临床药学科，锡林浩特 026000
- Publication Type:Journal Article
- Keywords:
Sodium-glucose transporter 2 inhibitors;
Diabetic ketoacidosis;
Dapagliflozin
- From:
Adverse Drug Reactions Journal
2023;25(7):444-445
- CountryChina
- Language:Chinese
-
Abstract:
A 48-year-old male patient received dapagliflozin, metformin and insulin glargine injection due to poor blood glucose control and the blood glucose control was acceptable. After 9 months, the patient′s food intake decreased due to swelling in the gum, and 3 days later, the patient developed nausea, vomiting, fatigue, and wheezing. The arterial blood gas analysis showed metabolic acidosis, random blood glucose 15.2 mmol/L, and urinary ketone body (+++). Dapagliflozin and other oral hypoglycemic drugs were stopped, symptomatic treatments such as insulin, fluid replacement, anti-infection, antiemesis, and correction of electrolyte disorder were given, and the patient′s condition was improved. It was considered that dapagliflozin caused ketoacidosis (DKA). The hypoglycemic treatment regimen was changed to subcutaneously injection of insulin aspart 30 injection 22 U in the morning and 16 U at night and oral metformin 0.5 g thrice daily, and the blood glucose control was acceptable. After that, no DKA symptoms recurred in the patient.
