Regulatory effect of Kisspeptin on hypothalamic-pituitary-ovarian axis

VernacularTitle:Kisspeptin对下丘脑-垂体-卵巢轴的调控作用
Author: Li YANG ¹ ; Qing WANG ; Zhi WANG ; Haoxu DONG ; Ling CHENG ; Dongmei HUANG
Author Information

1. 华中科技大学同济医学院附属同济医院中西医结合研究所，武汉430030
Publication Type:Journal Article
Keywords: Kisspeptin; Hypothalamus; Pituitary; Ovary
From: Chinese Journal of Reproduction and Contraception 2021;41(2):177-183
CountryChina
Language:Chinese
Abstract: Kisspeptin is an important neuropeptide regulating female reproductive function. It mainly acts on the upstream of hypothalamic gonadotropin-releasing hormone (GnRH) neurons. It binds to the corresponding receptor GPR54 on GnRH neurons to stimulate the release of GnRH, which leads to a series of subsequent activities of the reproductive axis. However, in recent years, it has been found that Kisspeptin exists not only in the central hypothalamus and pituitary, but also in the peripheral ovary, indicating that Kisspeptin not only regulates the female reproductive function in the central, but also plays a local role in the ovary. Kisspeptin is not only involved in the regulation of oocyte, granulosa cell and luteal function, but also affected by gonadotropin, photoperiod, sympathetic nerve and metabolism. This article reviews the central regulation effect and the local ovarian role of of kisspeptin.