Effect of intrauterine microbial on embryo implantation and its mechanism
10.3760/cma.j.cn101441-20191209-00546
- VernacularTitle:宫腔微生物对胚胎种植的影响及机制研究进展
- Author:
Linna MA
1
;
Jun ZHAI
1
Author Information
1. 郑州大学第一附属医院生殖与遗传专科医院 450052
- Publication Type:Journal Article
- Keywords:
Intrauterine microbiome;
Reproductive technology, assisted;
Embryo implantation
- From:
Chinese Journal of Reproduction and Contraception
2021;41(2):173-176
- CountryChina
- Language:Chinese
-
Abstract:
With the development of 16S rRNA sequencing technology and metagenomics, the colonization of microbial flora in uterine cavity has been confirmed. The implantation rate, the clinical pregnancy rate and pregnancy outcome of patients with Lactobacillus dominated endometrial microbiome after assisted reproductive technology were higher. The mechanism of endometrial microorganisms in embryo implantation and pregnancy maintenance is still unclear. At present, it is believed that the possible mechanism is involved in endometrial immune regulation and the direct interaction with endometrium to regulate the expression of inflammatory factors, thus affecting the process of endometrial decidualization, embryo implantation, and the maintenance of homeostasis by symbiotic microorganisms. This article reviews the recent studies on the sources and components of the endometrial microbiota, the influence and mechanism of endometrial microbiota on the pregnancy outcome of assisted reproductive technology, and aims to provide new ideas for future research on the role of endometrial microorganisms on embryo implantation.
