Effect of frozen semen from sperm bank on birth defects in assisted reproduction technology in China: a meta-analysis
10.3760/cma.j.cn101441-20200406-00192
- VernacularTitle:中国使用精子库冷冻精液助孕对子代出生缺陷影响的meta分析
- Author:
Guangbao LIU
1
;
Ranran KANG
1
;
Zhi JIAO
1
;
Xuli JIN
1
;
Di ZHU
1
;
Jie CHEN
1
Author Information
1. 山东大学公共卫生学院儿少卫生与妇幼保健学系，山东大学生殖医学研究中心，国家辅助生殖与优生工程技术研究中心，生殖内分泌教育部重点实验室，济南 250000
- Publication Type:Journal Article
- Keywords:
Frozen semen;
Reproductive technology, assisted;
Birth defects;
Meta-analysis
- From:
Chinese Journal of Reproduction and Contraception
2021;41(4):342-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the incidence of birth defects in offspring using frozen semen from sperm banks by meta-analysis, to provide scientific evidence for the safety and reliability of frozen semen in assisted reproductive technology (ART).Methods:China National Knowledge Infrastructure (CNKI), Wanfang Digital Database (Wanfang), VIP Citation Database (VIP), CBMDisc and PubMed were searched about birth defects using frozen semen in ART since the establishment to October 1, 2019. Literatures were screened according to the predefined inclusion and exclusion criteria and evaluated based on the STROBE statement.Results:Thirteen studies with 33 398 cases were included, the rate of birth defects using frozen semen was 1.09% (95% CI=0.85%-1.32%), lower than that published by the Chinese Ministry of Health (1.53%, P<0.001). The rate was 1.06% (95% CI=0.78%-1.35%) in artificial insemination by donor (AID), 0.60% (95% CI=0.03%-1.22%) in in vitro fertilization (IVF) and 1.35% (95% CI=0.06%-2.75% ) in intracytoplasmic sperm injection (ICSI), the difference was not statistically significant ( P=0.785). Among the birth defects, the cardiovascular system had the highest rate, followed by the central nervous system and musculoskeletal system and congenital urogenital system and so on. Conclusion:ART with cryopreserved donor sperm does not increase the risk of birth defects. However, more studies with large sample sizes are needed to confirm this conclusion because some papers with low study quality were included in this study.
