Advances on the immunometabolism in regulating the endometrial microenvironment and maternal-fetal tolerance
10.3760/cma.j.cn101441-20200323-00152
- VernacularTitle:免疫代谢调控子宫内膜微环境和母-胎免疫耐受的研究进展
- Author:
Lianghui DIAO
1
;
Songchen CAI
1
;
Su LIU
1
;
Chunyu HUANG
1
;
Longfei LI
1
;
Yuye LI
1
;
Yong ZENG
1
Author Information
1. 深圳市围着床期生殖免疫重点实验室，深圳中山生殖与遗传研究所，深圳中山泌尿外科医院生殖医学临床研究中心 518045
- Publication Type:Journal Article
- Keywords:
Immunomodulation;
Metabolism;
Endometrium;
Cellular microenvironment;
Embryo implantation;
Immune tolerance;
Pregnancy immunity
- From:
Chinese Journal of Reproduction and Contraception
2021;41(5):448-455
- CountryChina
- Language:Chinese
-
Abstract:
The endometrial microenvironment and the immune regulation of pregnancy is a recent focus and challenge in the field of reproductive immunology. During the establishment of pregnancy, the immune cells assist in shaping a fetus-friendly immune microenvironment through adaptive reprogramming, thereby allowing the embryo to obtain "immune privilege". Immunometabolism is an emerging research field that has been developing rapidly in the last decade, focusing on the interaction between the immunology and metabolism and their roles in the physiopathology. However, the current evidence regarding how immunometabolism is involved in the regulation of the endometrial microenvironment and maternal-fetal immune tolerance is insufficient. In light of the implications of tumor immunometabolism for immunometabolism in pregnancy, the metabolic pathways of immune cell differentiation and function are reviewed for their potential regulatory role in shaping the maternal-fetal tolerance microenvironment. The relationship between metabolic and nutritional abnormalities and pregnancy disorders is analyzed. Finally, the possibility of improving pregnancy outcomes through immunometabolic inhibitors or dietary interventions is explored from a clinical application perspective.
