Bradyarrhythmia induced by misuse of excessive Cortex Periplocae
10.3760/cma.j.cn114015-20230316-00190
- VernacularTitle:误用超量香加皮致缓慢性心律失常
- Author:
Xiaoyuan BIAN
1
;
Chao CUI
;
Wen HUANG
;
Hui LI
;
Guiming LIU
Author Information
1. 山东省淄博市中医医院心血管病三科，淄博 255300
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Medication errors;
Plant poisoning;
Cardiotoxicity;
Cortex Periplocae;
Cortex Acanthopanax Radicis
- From:
Adverse Drug Reactions Journal
2023;25(5):318-320
- CountryChina
- Language:Chinese
-
Abstract:
A 41-year-old female patient took decoction of Chinese medicine (containing 10 g of Fructus Lycii, 10 g of Radix Ginseng Rubra, and 15 g of Cortex Acanthopanax Radicis) by herself due to trigeminal neuralgia. After about 6 hours of medication, the patient developed palpitate suddenly, woke up in sleep, accompanied by dizziness. Her blood pressure was 95/63 mmHg. The electrocardiogram showed atrial fibrillation, and ventricular rate was 45 beats/min. Symptomatic treatments such as elevation of hypertension and improvement of myocardial metabolism were given, but the patient′s symptoms were not improved. After that, she developed nausea and vomiting, her heart rate decreased to 35 beats/min, and blood pressure decreased to 87/36 mmHg. Electrocardiogram showed junctional escape rhythm and T-wave change. Electrocardiogram monitoring and continuous oxygen inhalation, and symptomatic and supportive treatments such as continuous IV pumping of dopamine and dobutamine, and polarized solution were given. Eight days after treatment, the patient′s condition was improved. Electrocardiogram showed sinus rhythm. The patient sent the traditional Chinese medicine to a professional institution for identification, and found that it contained Cortex Periplocae, while the original prescription was Cortex Acanthopanax Radicis. Therefore, it is considered that the patient′s arrhythmia was caused by mistakenly use of excessive Cortex Periplocae.
