Research progress of circular RNA in diseases related to trophoblast dysfuction

VernacularTitle:环状RNA在滋养细胞功能障碍相关疾病中的研究进展
Author: Laidi XIE ¹ ; Aixia LIU ¹
Author Information

1. 浙江大学医学院附属妇产科医院，杭州　310006
Publication Type:Journal Article
Keywords: Circular RNA; Preeclampsia; Recurrent spontaneous abortion; Fetal growth restriction; Endometrial receptivity
From: Chinese Journal of Reproduction and Contraception 2021;41(9):850-856
CountryChina
Language:Chinese
Abstract: Circular RNAs (circRNAs), non-coding RNA with stable circular covalently closed structures, provide new biomarkers for the diagnosis and treatment of various diseases and play an important role in the development of tumors. Trophoblast dysfunction can cause embryo implantation failure, placental dysplasia, and insufficient vascular remodeling at the maternal-fetal interface, leading to early pregnancy loss, preeclampsia (PE), premature delivery, and fetal growth restriction (FTR). Here, we review recent research progress in circRNAs in diseases related to trophoblast dysfunction such as PE, recurrent spontaneous abortion (RSA) and FGR. In this way, we can better understand the pathogenesis of pregnancy-related diseases and come up with new ideas for their future diagnosis and treatment.