Analysis of the clinical pregnancy outcomes of infertile patients with non-ovulation disorder receiving natural cycle or ovulation induction cycle with artificial intrauterine insemination with the husband's sperm
10.3760/cma.j.cn101441-20200319-00144
- VernacularTitle:非排卵障碍不孕患者宫腔内夫精人工授精自然周期与促排卵周期妊娠结局分析
- Author:
Nan CHEN
1
;
Xiaoyang FEI
1
;
Meiyan JIANG
1
Author Information
1. 杭州市妇产科医院生殖医学中心 310008
- Publication Type:Journal Article
- Keywords:
Artificial insemination with intrauterine;
Pregnancy outcome;
Ovulation induction cycle;
Natural cycle
- From:
Chinese Journal of Reproduction and Contraception
2021;41(3):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pregnancy outcomes of non-ovulation disorder infertile patients with natural cycle or ovulation-promoting cycle of intrauterine insemination (IUI) with the husband's sperm.Methods:A retrospective cohort study was carried out on a total of 821 cycles of non-ovulation disorder infertile patients who received IUI with ≤35 years old at the Hangzhou Women's Hospital from January 2014 to October 2019. According to whether the ovulation induction, they were divided into natural cycle group (group N, n=225) and ovulation induction cycle group (group O, n=596). Meanwhile, according to the etiology of IUI infertility [unexplained infertility (A), men's semen abnormalities (B), sexual dysfunction (C), unilateral tubal obstruction (D)], they were divided into four subgroups, namely NA group ( n=67), NB group ( n=94), NC group ( n=39), ND group ( n=25) and OA group ( n=233), OB group ( n=217), OC group ( n=51), OD group ( n=95). The general information, clinical pregnancy rate, abortion rate, ectopic pregnancy rate, multiple pregnancy rate, and other indicators of patients were compared between group N and group O. Clinical pregnancy rate, abortion rate, ectopic pregnancy rate, and multiple pregnancy rate were compared between each two subgroups. Results:1) The multiple pregnancy rate of ovulation induction cycle group was 13.1% (13/99), more than 0% (0/30) of natural cycle group, the differences was statistically significant ( P=0.038). There were no significant differences between the two groups in clinical pregnancy rate, abortion rate, and ectopic pregnancy rate (all P>0.05). 2) There were no significant differences between each two subgroups in clinical pregnancy rate, abortion rate, ectopic pregnancy rate and multiple birth rate (all P>0.05). Conclusion:For non-ovulatory infertile patients with IUI, the ovulation induction may not increase the clinical pregnancy rate of the patient, but may increase the multiple birth rate.
