Research progress on assisted reproductive technology effects on pregnancy outcomes and women's long-term health
10.3760/cma.j.cn101441-20200228-00092
- VernacularTitle:辅助生殖技术治疗对妊娠结局及女性远期健康影响的研究进展
- Author:
Mulan HE
1
;
Xiaoxi SUN
1
Author Information
1. 复旦大学附属妇产科医院，上海 200011
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Pregnancy complications;
Endocrine system diseases;
Breast neoplasms;
Genital neoplasms, female
- From:
Chinese Journal of Reproduction and Contraception
2021;41(3):264-269
- CountryChina
- Language:Chinese
-
Abstract:
Assisted reproductive technology (ART) offers infertile women the chance to have children, but the unphysiological interventions involved in the treatment may increase the risk of a serious adverse pregnancy outcome by affecting the pregnancy environment. In addition, the use of ovulation drugs, such as clomiphene citrate, gonadotrophin, make the body sex hormone levels rise. Whether periodic use of stimulating ovulation drugs repeatedly increases the risk of breast cancer and gynecological tumors, such as endometrial cancer and ovarian cancer, as well as endocrine metabolism system disorders and cardiovascular system diseases has not been determined. Furthermore, the patient's age, body mass index, underlying chronic disease and infertility factors are all likely to be confounding factors. It needs more further follow-up cohort study and uses big data to clarify ART influence on female pregnancy outcomes and the long-term health gradually. It will provide important reference data for reproductive doctors to make reasonable treatment plan according to the specific condition of patients with the purpose of protecting women's long-term health.
