Correlation analysis of osteomyelitis and plasma atherosclerosis index in diabetic foot
10.3969/j.issn.1006-6187.2025.08.007
- VernacularTitle:糖尿病足骨髓炎与血浆动脉粥样硬化指数相关性的研究
- Author:
Xi FU
1
;
Meiling LAO
;
Weihong HE
;
Jiayou PENG
Author Information
1. 528000 佛山市中医院放射科
- Publication Type:Journal Article
- Keywords:
Atherogenic index of plasma;
Osteomyelitis in diabetic foot;
Magnetic resonance imaging
- From:
Chinese Journal of Diabetes
2025;33(8):592-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the MRI features of diabetic foot osteomyelitis(DFO)and its correlation with the atherogenic index of plasma(AIP).Methods The clinical data of 96 DF patients who were treated in the our hospital from January 2016 to December 2022 were collected.According to whether DFO occurs,the patients were divided into two groups:DF group(n=52)and DFO group(n=44).The differences of age,sex,course of diabetes,AIP and other clinical indicators between the two groups were compared.Logistic regression was used to analyze the influencing factors of DFO,and receiver operating characteristic(ROC)curve was used to analyze the efficacy of AIP and common clinical indicators in predicting DFO.Results The main manifestations of DFO on MRI were soft tissue cellulitis,abscess(50/96),osteomyelitis(48/96),sinus(45/96),and Charcot's joint(12/96).Among 48 cases of osteomyelitis,4 cases were confirmed as false positive by bone puncture biopsy,13(13/44)cases had exposed bone tissue,14(14/44)cases were confirmed by bone puncture biopsyand17(17/44)cases were positive for bone pathogen culturewhichincluding 9 cases of Gram-positive bacteria(5 cases of Staphylococcus aureus,3 cases of Staphylococcus epidermidis,and 1 case of Staphylococcus hemolysis);5 cases of Gram-negative bacteria(3 cases of Pseudomonas aeruginosa,1 case of Proteus mirabilis,and 1 case of Klebsiella pneumoniae)and 3 cases were mixed bacterial infections.Compared with the DF group,the BMI,AIP,High sensitivity C reactive protein,and smoking rate of patients in the DFO group increased(P<0.05).Binary logistic regression analysis showed that AIP and smoking were the influencing factors of DFO.The ROC curve analysis showed that the area under the ROC curve of AIP predicting DFO in DM patients was 0.738,with a sensitivity of 72.7%,a specificity of 73.1%,and an optimal cutoff value of 0.19.The Delong test showed that AIP has an advantage in predicting DFO(P<0.05).Conclusions MRI can better display the involvement of soft tissue and bone joints in DFO feet.AIP and smoking are influencing factors of DFO.AIP is a monitoring indicator for the prevention and treatment of DFO.
