Clinical analysis of infertility patients undergoing in vitro fertilization with a levonorgestrel intrauterine system in situ after conservative treatment of early well-differentiated endometrial adenocarcinoma and atypical endometrial hyperplasia
10.3760/cma.j.cn101441-20200312-00123
- VernacularTitle:子宫内膜癌保守治疗后的不孕患者带左炔诺孕酮宫内节育系统行体外受精助孕的临床分析
- Author:
Duoduo ZHANG
1
;
Chengyan DENG
1
;
Qi YU
1
;
Lingya PAN
1
;
Hanbi WANG
1
Author Information
1. 中国医学科学院北京协和医院妇科内分泌与生殖中心 100730
- Publication Type:Journal Article
- Keywords:
Infertility;
Endometrial adenocarcinoma;
Endometrial hyperplasia with atypia;
Fertilization in vitro;
Embryo transfer;
Levonorgestrel intrauterine sy
- From:
Chinese Journal of Reproduction and Contraception
2021;41(3):237-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of a novel in vitro fertilization (IVF) strategy with levonorgestrel intrauterine system (Mirena) in situ in infertility patients after successful conservative treatment of early well-differentiated endometrial adenocarcinoma (EC) and atypical endometrial hyperplasia (AEH). Methods:The clinical characteristics of infertility patients after a complete regression of previous EC and AEH who underwent IVF with a Mirena in situ from March 2018 to December 2019 in Center for Gynecological Endocrinology & Reproductive Medicine, Peking Union Medical College Hospital were retrospectively analyzed. These patients underwent one or more cycles to harvest at least 4 blastocysts cryopreserved, before removing the Mirena and re-evaluating the endometrium. Then the outcomes of frozen-thawed embryo transfer (FET) were commenced. Results:A total of 20 patients were included with a median age of 33 years. The complete regression of endometrial lesion was achieved at 4.3 months. Thirty-four IVF cycles were conducted in total, leading to a median oocytes retrieved of 8. We had attempted 21 embryo trasfer but only 14 cycles were effective, and 5 patients got clinical pregnancy and 2 patients had ongoing pregnancy.Conclusion:It is a supposedly practical way that IVF with the Mirena until pooling enough blastocysts before removing the device and initiating embryo trasfer for assisting reproduction and endometrial protection in patients after fertility-sparing treatment of EC or AEH.
