Research advances of nuclear factor erythroid 2 related factor 2/antioxidant response element signaling pathway in reproductive system
10.3760/cma.j.cn101441-20200604-00330
- VernacularTitle:核因子E2相关因子2/抗氧化反应元件信号通路在生殖系统中的研究进展
- Author:
Yucong MA
1
;
Aimin YANG
;
Shuancheng ZHANG
;
Huilan DU
Author Information
1. 河北中医学院，石家庄 050091
- Publication Type:Journal Article
- Keywords:
Nuclear factor erythroid 2 related factor 2/antioxidant response element signaling pathways;
Reproductive system;
Oxidative stress
- From:
Chinese Journal of Reproduction and Contraception
2021;41(12):1154-1159
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress is the imbalance between oxidation and anti-oxidation, and reactive oxygen species participate in the physiological and pathological process of reproductive system. Nuclear factor erythroid 2 related factor 2/antioxidant response element (Nrf2/ARE) is an important antioxidant stress pathway. Nrf2 can be activated into the nucleus by various factors such as reactive oxygen species and antioxidants, and combine with small Maf protein and ARE to regulate the expression of various antioxidant enzymes, thus playing an antioxidant role. Studies have shown that the Nrf2/ARE antioxidant pathway plays an important regulatory role in reproductive system diseases. In this paper, the research progress of Nrf2/ARE signaling pathway in reproductive system at home and abroad in recent years is reviewed, and the existing problems and future research directions are discussed and prospected.
