Liver injury due to Anshen Bunao liquid (安神补脑液): report of 2 cases
10.3760/cma.j.cn114015-20220411-00300
- VernacularTitle:安神补脑液致肝损伤2例
- Author:
Jinchun LIU
1
;
Fan ZHANG
Author Information
1. 南京大学医学院附属鼓楼医院药学部，南京临床药学中心，南京 210008
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Anshen Bunao liquid;
Drug-induced liver injury
- From:
Adverse Drug Reactions Journal
2023;25(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Two patients (patient 1, a 49-year-old female; patient 2, a 51-year-old female) took Anshen Bunao liquid 10 ml twice daily orally by themselves because of poor sleep. None of the 2 patients had concomitant medications. Patient 1 and patient 2 developed fatigue and poor appetite after 7 and 10 days of Anshen Bunao liquid treatment, respectively. Laboratory tests showed that alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were 1 147 U/L, 1 271 U/L, 215 U/L and 805 U/L, 333 U/L, 227 U/L, respectively. Then Anshen Bunao liquid was stopped and hepatoprotective therapy was given. Seven days later, symptoms of fatigue and poor appetite in the 2 patients were improved, amd laboratory tests showed that the levels of ALT, AST, ALP decreased to 222 U/L, 396 U/L, 122 U/L and 85 U/L, 23 U/L, 129 U/L, respectively. Patient 1 took Anshen Bunao liquid again. Two days later, she developed abdominal discomfort with vomiting, ALT was 409 U/L, and AST was 339 U/L. After stopping the drug and giving liver-protective treatments for nearly 4 months, ALT was 32 U/L, AST was 22 U/L, and ALP was 89 U/L. Patient 2 did not take the drug again. Re-examination after 138 days after discharge, ALT was 39 U/L, AST was 28 U/L, and ALP was 130 U/L.
