Effect of chronic paternal stress on reproductive cell reprogramming and its mechanism
10.3760/cma.j.cn101441-20200807-00430
- VernacularTitle:父体慢性应激对生殖细胞重编程的影响及其机制
- Author:
Ming CHEN
1
;
Hao XIAO
;
Qingxian LI
;
Hui WANG
;
Liaobin CHEN
Author Information
1. 武汉大学中南医院骨科，武汉 430071
- Publication Type:Journal Article
- Keywords:
Chronic stress;
Epigenetic modification;
Germ cells reprogramming
- From:
Chinese Journal of Reproduction and Contraception
2022;42(4):425-430
- CountryChina
- Language:Chinese
-
Abstract:
Paternal chronic stress can not only cause damage to multiple organs and systems of the paternal itself, but also transmit the harm to the offspring. Moreover, the harm caused by paternal chronic stress to the offspring is related to reprogramming of germ cells. The current views believe that the epigenetic modification is responsible for the transformation of germ cell fate and maintenance of developmental potential. Therefore, once the stress factors lead to epigenetic modification of the paternal germ cells in a certain period, it reprogram the germ cells, which can further transmit the harm to the offspring or even multiple generations. However, the mechanism of reprogramming of germ cells caused by chronic paternal stress has not been fully elucidated. This article reviewed the harm of paternal chronic stress to the paternal itself and its offspring for multiple generations, and combined the latest research progress to explore the mechanism by which paternal chronic stress affects reprogramming of reproductive cells, with a view to provide more theoretical basis for paternal-originated diseases.
